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Septerna, Inc. (SEPN)

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Sector: Pharmaceutical Preparations

Industry: Biotechnology

Septerna Inc logo

Septerna Inc

NASDAQ:SEPNHealthcare
-1.15%$40.41
AH Close$40.41+0.00%vs close
Mkt Cap$1.89B
Float26.91M
O/S46.68M
Inst Own101.2%
SI11.5%
Dilution
Septerna Inc logoNASDAQ:SEPN$40.41-1.15%
Historical Data
DateOpenHighLowCloseVolume
Key Metrics
Market Cap$1.89B
Enterprise Value--
P/E Ratio--
Est. Net Cash/Share--
Institutional Ownership101.21%

based on 46.68M shares outstanding

SectorHealthcare
IndustryBiotechnology
ExchangeNASDAQ
CountryUSUS
IPO DateOct 25, 2024
Shares Outstanding46.68M
Float26.91M
Company Overview

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.

It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease.

In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease.

It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets.

The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

Leadership

Abraham Bassan, M.S.

Director

Alan Ezekowitz, M.D., D.Phil.

Director

Bernard Coulie, M.D., Ph.D., M.B.A.

Director

Daniel Long, D.Phil.

Senior Vice President, Drug Discovery

Employees

123

Country

US

Sector

Healthcare

Website

septerna.com

Analyst Coverage
Analyst Coverage
ConsensusBuy
Price Target (median, last 90d)
$50.00+23.7%
Low $49High $60
Ratings Distribution
BUY
9
HOLD
0
SELL
0
TOTAL9
Insider Trading
InsiderTypeShares
Bhatt Elizabeth profile photoBhatt ElizabethSale2.9K
Bhatt Elizabeth profile photoBhatt ElizabethOption Exercise4.0K
Bhatt Elizabeth profile photoBhatt ElizabethOption Exercise4.0K
Bhatt Elizabeth profile photoBhatt ElizabethSale1.1K
Patni Rajiv profile photoPatni RajivGrant/Award275.0K
Long Daniel D. profile photoLong Daniel D.Option Exercise3.3K
Shareholders
101.2%
Institutional
(156)
11.8%
Insiderⓘ
(8)
15.3%
5%+ Owners
(2)
-
Unattributed (incl. retail)ⓘ
Institutional101.2%
Insider11.8%
5%+ Beneficial15.3%
Sources: 13F, Form 4, 13D/13GO/S: 46.7M · as of 5 Aug 2026 · SEC cover page
Insiders & Institutional Holders
52-Week Range
$17.55$51.10
$40.41(68th percentile)
Volume
Average Daily Volume403.78K
200.31K today vs 403.78K avg(-50%)

30d Avg

403.78K

60d Avg

366.77K

90d Avg

390.55K

Earnings
Dividend History
No dividend history available
Compliance Status
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