Septerna, Inc. (SEPN)
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.
Sector: Pharmaceutical Preparations
Industry: Biotechnology
Septerna Inc
| Date | Open | High | Low | Close | Volume |
|---|---|---|---|---|---|
based on 46.68M shares outstanding
Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases.
It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease.
In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease.
It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets.
The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.
Leadership
Abraham Bassan, M.S.
Director
Alan Ezekowitz, M.D., D.Phil.
Director
Bernard Coulie, M.D., Ph.D., M.B.A.
Director
Daniel Long, D.Phil.
Senior Vice President, Drug Discovery
Employees
123
Country
US
Sector
Healthcare
Website
septerna.com
| Insider | Title | Type | Shares | Value | Date |
|---|---|---|---|---|---|
| President and COO | Sale | 2.9K | $109.3K | Oct 15, 2026 | |
| President and COO | Option Exercise | 4.0K | -- | Oct 15, 2026 | |
| President and COO | Option Exercise | 4.0K | $27.2K | Oct 15, 2026 | |
| President and COO | Sale | 1.1K | $40.3K | Oct 15, 2026 | |
| Chief Medical Officer | Grant/Award | 275.0K | -- | Sep 8, 2026 | |
| SVP, Drug Discovery | Option Exercise | 3.3K | -- | Sep 1, 2026 |
| Name | Shares | % | Source |
|---|---|---|---|
RA Capital Management, L.P. · also on 13F· may incl. warrants· filed Nov 2024 | 7.0M | 15.0% | 13D |
RA CAPITAL MANAGEMENT, L.P. | 7.0M | 15.0% | 13F |
Third Rock Ventures V, L.P. · may incl. warrants· filed May 2025 | 6.2M | 13.3% | 13G |
TRV GP V, LLC | 6.2M | 13.3% | 13F |
DRIEHAUS CAPITAL MANAGEMENT LLC · also on 13F· may incl. warrants· filed Jun 2025 | 4.7M | 10.0% | 13G |
DRIEHAUS CAPITAL MANAGEMENT LLC | 4.4M | 9.5% | 13F |
Third Rock Ventures VI, L.P. 10% Owner | 4.2M | 9.0% | FORM 4 |
TRV GP VI, LLC | 4.2M | 9.0% | 13F |
Samsara BioCapital, LLC | 3.1M | 6.7% | 13F |
GOLDMAN SACHS GROUP INC | 3.1M | 6.6% | 13F |
Insiders
- Bhatt ElizabethPresident and COO
- Patni RajivChief Medical Officer
- Long Daniel D.SVP, Drug Discovery
- Third Rock Ventures V, L.P.10% Owner
- RA CAPITAL MANAGEMENT, L.P.Director
- Shaikhly SamiraChief People Officer
- Kim Jae B.Chief Medical Officer
- Labrucherie Gil MChief Financial Officer
- Klein UweSVP, Biological Sciences
- Wilson Mark AndrewChief Legal Officer
based on 46.68M shares outstanding
30d Avg
403.78K
60d Avg
366.77K
90d Avg
390.55K